miR-4458 directly targets IGF1R to inhibit cell proliferation and promote apoptosis in hemangioma
Hemangiomas (HAs) are benign neoplasms of the vasculature. MicroRNA-4458 (miR-4458) has been reported to function as a tumor suppressor in multiple malignancies, but its biological function in HAs remains unknown. In the present study, the potential role of miR-4458 in HA-derived endothelial cells (...
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| Published in | Experimental and therapeutic medicine Vol. 19; no. 4; pp. 3017 - 3023 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
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Spandidos Publications
01.04.2020
Spandidos Publications UK Ltd D.A. Spandidos |
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| Abstract | Hemangiomas (HAs) are benign neoplasms of the vasculature. MicroRNA-4458 (miR-4458) has been reported to function as a tumor suppressor in multiple malignancies, but its biological function in HAs remains unknown. In the present study, the potential role of miR-4458 in HA-derived endothelial cells (HDECs) was investigated. Firstly, reverse-transcription-quantitative PCR analysis was used to confirm the expression of miR-4458 in HDECs following transfection with miR-4458 mimics or inhibitor. Subsequently, MTT and EdU assays were performed and subsequently determined that miR-4458 overexpression significantly inhibited proliferation, and knockdown promoted cell proliferation in HDECs. Flow cytometry analysis revealed that miR-4458 overexpression induced cell cycle arrest, whereas knockdown reversed G0/G1 phase arrest and apoptosis. Furthermore, insulin-like growth factor 1 receptor (IGF1R) was identified as a target of miR-4458. IGF1R knockdown enhanced the effects of miR-4458 on cell proliferation, cell cycle G0/G1 phase arrest and apoptosis in HDECs. Taken together, the results revealed that miR-4458 targeting of IGF1R may serve as a novel therapeutic strategy for treating patients with HAs. |
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| AbstractList | Hemangiomas (HAs) are benign neoplasms of the vasculature. MicroRNA-4458 (miR-4458) has been reported to function as a tumor suppressor in multiple malignancies, but its biological function in HAs remains unknown. In the present study, the potential role of miR-4458 in HA-derived endothelial cells (HDECs) was investigated. Firstly, reverse-transcription-quantitative PCR analysis was used to confirm the expression of miR-4458 in HDECs following transfection with miR-4458 mimics or inhibitor. Subsequently, MTT and EdU assays were performed and subsequently determined that miR-4458 overexpression significantly inhibited proliferation, and knockdown promoted cell proliferation in HDECs. Flow cytometry analysis revealed that miR-4458 overexpression induced cell cycle arrest, whereas knockdown reversed G0/G1 phase arrest and apoptosis. Furthermore, insulin-like growth factor 1 receptor (IGF1R) was identified as a target of miR-4458. IGF1R knockdown enhanced the effects of miR-4458 on cell proliferation, cell cycle G0/G1 phase arrest and apoptosis in HDECs. Taken together, the results revealed that miR-4458 targeting of IGF1R may serve as a novel therapeutic strategy for treating patients with HAs. Hemangiomas (HAs) are benign neoplasms of the vasculature. MicroRNA-4458 (miR-4458) has been reported to function as a tumor suppressor in multiple malignancies, but its biological function in HAs remains unknown. In the present study, the potential role of miR-4458 in HA-derived endothelial cells (HDECs) was investigated. Firstly, reverse-transcription-quantitative PCR analysis was used to confirm the expression of miR-4458 in HDECs following transfection with miR-4458 mimics or inhibitor. Subsequently, MTT and EdU assays were performed and subsequently determined that miR-4458 overexpression significantly inhibited proliferation, and knockdown promoted cell proliferation in HDECs. Flow cytometry analysis revealed that miR-4458 overexpression induced cell cycle arrest, whereas knockdown reversed G0/G1 phase arrest and apoptosis. Furthermore, insulin-like growth factor 1 receptor (IGF1R) was identified as a target of miR-4458. IGF1R knockdown enhanced the effects of miR-4458 on cell proliferation, cell cycle G0/G1 phase arrest and apoptosis in HDECs. Taken together, the results revealed that miR-4458 targeting of IGF1R may serve as a novel therapeutic strategy for treating patients with HAs. Key words: hemangioma, microRNA-4458, insulin-like growth factor 1 receptor, proliferation |
| Audience | Academic |
| Author | Ye, Kaichuang Hu, Gang Liu, Xianluo Yang, Chunjian Wu, Maosong Tang, Yongsheng |
| AuthorAffiliation | 1 Department of General Surgery, The Second People's Hospital of Hefei, Hefei, Anhui 230011, P.R. China 2 Department of Vascular Surgery, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 230011, P.R. China |
| AuthorAffiliation_xml | – name: 2 Department of Vascular Surgery, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 230011, P.R. China – name: 1 Department of General Surgery, The Second People's Hospital of Hefei, Hefei, Anhui 230011, P.R. China |
| Author_xml | – sequence: 1 givenname: Maosong surname: Wu fullname: Wu, Maosong organization: Department of General Surgery, The Second People's Hospital of Hefei, Hefei, Anhui 230011, P.R. China – sequence: 2 givenname: Yongsheng surname: Tang fullname: Tang, Yongsheng organization: Department of General Surgery, The Second People's Hospital of Hefei, Hefei, Anhui 230011, P.R. China – sequence: 3 givenname: Gang surname: Hu fullname: Hu, Gang organization: Department of General Surgery, The Second People's Hospital of Hefei, Hefei, Anhui 230011, P.R. China – sequence: 4 givenname: Chunjian surname: Yang fullname: Yang, Chunjian organization: Department of General Surgery, The Second People's Hospital of Hefei, Hefei, Anhui 230011, P.R. China – sequence: 5 givenname: Kaichuang surname: Ye fullname: Ye, Kaichuang organization: Department of Vascular Surgery, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 230011, P.R. China – sequence: 6 givenname: Xianluo surname: Liu fullname: Liu, Xianluo organization: Department of General Surgery, The Second People's Hospital of Hefei, Hefei, Anhui 230011, P.R. China |
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| Cites_doi | 10.1097/SAP.0000000000000426 10.3892/or.2017.5515 10.1136/mp.54.5.311 10.1016/j.ejphar.2018.10.022 10.18632/oncotarget.16327 10.3892/ijo.2014.2512 10.1002/mc.22470 10.1016/j.bbrc.2019.08.075 10.3892/mmr.2018.9409 10.1016/j.bbrc.2015.11.066 10.1001/jamafacial.2016.1188 10.1016/j.bbrc.2015.06.087 10.1038/ncomms14892 10.2147/CMAR.S196862 10.1074/jbc.M110.118620 10.1006/meth.2001.1262 10.1016/j.gene.2017.07.046 10.1016/j.jbior.2014.09.013 10.1007/s00431-014-2403-6 10.1158/1078-0432.CCR-08-1818 10.1016/j.biopha.2015.08.031 10.1007/s13402-019-00484-6 10.1530/EC-17-0158 10.1161/ATVBAHA.118.310908 10.1039/c4fo01141d 10.1159/000373991 10.3892/ol.2016.5176 10.1159/000366342 10.3892/or.2018.6512 10.18632/oncotarget.3023 10.1016/j.clindermatol.2014.10.009 10.1016/j.urology.2016.02.006 10.1016/j.molmed.2014.06.005 10.1097/PRS.0000000000003349 10.1038/aps.2017.73 10.1371/journal.pgen.1005879 10.1089/scd.2014.0376 |
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| Keywords | hemangioma insulin-like growth factor 1 receptor microRNA-4458 proliferation |
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| Snippet | Hemangiomas (HAs) are benign neoplasms of the vasculature. MicroRNA-4458 (miR-4458) has been reported to function as a tumor suppressor in multiple... |
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| SubjectTerms | Analysis Apoptosis Binding sites Cancer Cell cycle Cell growth Colorectal cancer Endothelium Experiments Flow cytometry Gene expression Health aspects Hemangioma Infection Insulin Kinases Lung cancer MicroRNA MicroRNAs Novels Polymerase chain reaction Proteins Scientific equipment industry Tumors |
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| Title | miR-4458 directly targets IGF1R to inhibit cell proliferation and promote apoptosis in hemangioma |
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