Heparan Sulfate Proteoglycan Signaling in Tumor Microenvironment

• Published in: International journal of molecular sciences Vol. 21; no. 18; p. 6588
• Main Authors: De Pasquale, Valeria, Pavone, Luigi Michele
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 09.09.2020; MDPI
• Subjects: Acids; Biosynthesis; Carcinogenesis; Collagen; Enzymes; Genes; Glycoproteins; Growth factors; Heparan sulfate; Heparan Sulfate Proteoglycans - chemistry; Heparan Sulfate Proteoglycans - metabolism; Humans; Ligands; Lung cancer; MAP Kinase Signaling System; Metastasis; Molecular Structure; Molecular Targeted Therapy; Mutation; Physiology; Prostate cancer; Proteins; Review; Signal transduction; Skin cancer; Thyroid cancer; Tumor Microenvironment; Tumors; remodeling; signaling; tumor microenvironment; heparan sulfate proteoglycans; extracellular matrix

In the last few decades, heparan sulfate (HS) proteoglycans (HSPGs) have been an intriguing subject of study for their complex structural characteristics, their finely regulated biosynthetic machinery, and the wide range of functions they perform in living organisms from development to adulthood. Fr...