Ultrasensitive and Quantitative Toxin Measurement Correlates With Baseline Severity, Severe Outcomes, and Recurrence Among Hospitalized Patients With Clostridioides difficile Infection

• Published in: Clinical infectious diseases Vol. 74; no. 12; pp. 2142 - 2149
• Main Authors: Alonso, Carolyn D, Kelly, Ciarán P, Garey, Kevin W, Gonzales-Luna, Anne J, Williams, David, Daugherty, Kaitlyn, Cuddemi, Christine, Villafuerte-Gálvez, Javier, White, Nicole C, Chen, Xinhua, Xu, Hua, Sprague, Rebecca, Barrett, Caitlin, Miller, Mark, Foussadier, Agnès, Lantz, Aude, Banz, Alice, Pollock, Nira R
• Format: Journal Article
• Language: English
• Published: US Oxford University Press 06.07.2022
• Subjects: Major and Commentaries; recurrence; clinical outcomes; toxin concentration; Clostridioides difficile

Abstract Background Stool toxin concentrations may impact Clostridioides difficile infection (CDI) severity and outcomes. We correlated fecal C difficile toxin concentrations, measured by an ultrasensitive and quantitative assay, with CDI baseline severity, attributable outcomes, and recurrence. Met...