Evaluating the sensitivity, reproducibility and flexibility of a method to test hard shell capsules intended for use in dry powder inhalers

• Published in: International journal of pharmaceutics Vol. 500; no. 1-2; pp. 316 - 325
• Main Authors: Chong, Rosalind H.E., Jones, Brian E., Díez, Fernando, Birchall, James C., Coulman, Sion A.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 16.03.2016
• Subjects: Calcium Chloride - chemistry; Capsule; Capsules - chemistry; Drug Storage; Dry powder inhaler; Dry Powder Inhalers; Gelatin; Gelatin - chemistry; Humidity; Hypromellose; Hypromellose Derivatives - chemistry; Magnesium Compounds - chemistry; Nitrates - chemistry; Puncture; Quality Assurance; Reproducibility of Results; Technology, Pharmaceutical - methods; Temperature; Dry powder inhaler; Capsule; Puncture; Hypromellose; Quality Assurance; Gelatin

[Display omitted] Pharmaceutical tests for hard shell capsules are designed for orally administered capsules. The use of capsules in dry powder inhalers is widespread and increasing and therefore more appropriate tests are required to ensure quality and determine if these capsules are fit for purpos...