Promising New Inhibitors of Tyrosyl-DNA Phosphodiesterase I (Tdp 1) Combining 4-Arylcoumarin and Monoterpenoid Moieties as Components of Complex Antitumor Therapy - Khomenko, Tatyana M.; Zakharenko, Alexandra L.; Chepanova, Arina A.; Ilina, Ekaterina S.; Zakharova, Olga D.; Kaledin, Vasily I.; Nikolin, Valeriy P.; Popova, Nelly A.; Korchagina, Dina V.; Reynisson, Jóhannes; Chand, Raina; Ayine-Tora, Daniel M.; et al. (International journal of molecular sciences, 2019)
Keywords: Animals; Cancer therapies; Carcinoma, Krebs 2 - drug therapy; Carcinoma, Krebs 2 - enzymology; Carcinoma, Krebs 2 - pathology; Carcinoma, Lewis Lung - drug therapy; Carcinoma, Lewis Lung - enzymology; Carcinoma, Lewis Lung - pathology; Chromatography; Cytotoxicity; Enzymes; Experiments; Female; Humans; Male; MCF-7 Cells; Mice; Monoterpenes - chemical synthesis; Monoterpenes - chemistry; Monoterpenes - pharmacology; Natural products; Neoplasm Proteins - antagonists & inhibitors; Neoplasm Proteins - metabolism; Phosphodiesterase Inhibitors - chemical synthesis; Phosphodiesterase Inhibitors - chemistry; Phosphodiesterase Inhibitors - pharmacology; Phosphoric Diester Hydrolases - metabolism; Structure-Activity Relationship; Tdp1 inhibitor; molecular modeling; neoflavone; coumarin; tumor; topoisomerase 1 inhibitors; cancer; chemical space; DNA repair enzymes; topotecan