HS, an Ancient Molecular Recognition and Information Storage Glycosaminoglycan, Equips HS-Proteoglycans with Diverse Matrix and Cell-Interactive Properties Operative in Tissue Development and Tissue Function in Health and Disease

• Published in: International journal of molecular sciences Vol. 24; no. 2; p. 1148
• Main Authors: Hayes, Anthony J., Melrose, James
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 06.01.2023; MDPI
• Subjects: Artificial Intelligence; Chemokines; Enzymes; Gene expression; Genomes; Glycosaminoglycans - metabolism; Growth factors; Heparan sulfate; Heparitin Sulfate - metabolism; Information storage; Ligands; Molecular Docking Simulation; Neural networks; Physiology; Proteins; Proteoglycans - metabolism; Review; Stem cells; cell/matrix interaction; heparan sulfate; sulfation motif; heparan sulfate proteoglycan; tissue homeostasis

Heparan sulfate is a ubiquitous, variably sulfated interactive glycosaminoglycan that consists of repeating disaccharides of glucuronic acid and glucosamine that are subject to a number of modifications (acetylation, de-acetylation, epimerization, sulfation). Variable heparan sulfate chain lengths a...