Single-Cell Analysis Identifies NOTCH3-Mediated Interactions between Stromal Cells That Promote Microenvironment Remodeling and Invasion in Lung Adenocarcinoma

• Published in: Cancer research (Chicago, Ill.) Vol. 84; no. 9; pp. 1410 - 1425
• Main Authors: Xiang, Handan, Pan, Yidan, Sze, Marc A., Wlodarska, Marta, Li, Ling, van de Mark, Karyn Ann, Qamar, Haleema, Moure, Casey J., Linn, Douglas E., Hai, Josephine, Huo, Ying, Clarke, James, Tan, Tze Guan, Ho, Samantha, Teng, Karen W., Ramli, Muhammad N., Nebozhyn, Michael, Zhang, Chunsheng, Barlow, Julianne, Gustafson, Corinne E., Gornisiewicz, Savanna, Albertson, Thomas P., Korle, Stephanie L., Bueno, Raphael, Moy, Lily Y., Vollmann, Elisabeth H., Chiang, Derek Y., Brandish, Philip E., Loboda, Andrey
• Format: Journal Article
• Language: English
• Published: United States American Association for Cancer Research 02.05.2024
• Subjects: Adenocarcinoma of Lung - genetics; Adenocarcinoma of Lung - metabolism; Adenocarcinoma of Lung - pathology; Cancer Biology; Cancer-Associated Fibroblasts - metabolism; Cancer-Associated Fibroblasts - pathology; Cell Communication; Humans; Lung Cancer; Lung Neoplasms - genetics; Lung Neoplasms - metabolism; Lung Neoplasms - pathology; Mice; Neoplasm Invasiveness; Receptor, Notch3 - genetics; Receptor, Notch3 - metabolism; Signal Transduction; Single Cell Technologies; Single-Cell Analysis; Stromal Cells - metabolism; Stromal Cells - pathology; Translational Research; Tumor Microenvironment

Cancer immunotherapy has revolutionized the treatment of lung adenocarcinoma (LUAD); however, a significant proportion of patients do not respond. Recent transcriptomic studies to understand determinants of immunotherapy response have pinpointed stromal-mediated resistance mechanisms. To gain a bett...