Alterations of Interneurons of the Gerbil Hippocampus after Transient Cerebral Ischemia: Effect of Pitavastatin

• Published in: Neuropsychopharmacology (New York, N.Y.) Vol. 30; no. 11; pp. 2014 - 2025
• Main Authors: HIMEDA, Toshiki, HAYAKAWA, Natsumi, TOUNAI, Hiroko, SAKUMA, Mio, KATO, Hiroyuki, ARAKI, Tsutomu
• Format: Journal Article
• Language: English
• Published: New York, NY Nature Publishing 01.11.2005; Nature Publishing Group
• Subjects: Animals; Biological and medical sciences; Cell Count - methods; Disease Models, Animal; Enzyme Inhibitors - administration & dosage; Gerbillinae; Hippocampus - cytology; Immunohistochemistry - methods; Interneurons - drug effects; Interneurons - metabolism; Ischemic Attack, Transient - metabolism; Male; Medical sciences; Neurology; Nitric Oxide Synthase Type I - metabolism; Parvalbumins - metabolism; Quinolines - administration & dosage; Time Factors; Vascular diseases and vascular malformations of the nervous system; Immunohistochemistry; Calcium; Toxicity; Central nervous system; Cardiovascular disease; Inorganic element; Encephalon; Interneuron; Binding protein; Ischemia; HMG-CoA reductase; interneurons; Enzyme; Rodentia; Statin derivative; Parvalbumin; Nitric-oxide synthase; Pitavastatin; Vertebrata; Mammalia; Animal; nNOS; Hydroxymethylglutaryl-CoA reductase; Oxidoreductases; Gerbil; Hippocampus

We investigated the immunohistochemical alterations of parvalbumin (PV)-expressing interneurons in the hippocampus after transient cerebral ischemia in gerbils in comparison with neuronal nitric oxide synthase (nNOS)-expressing interneurons. We also examined the effect of 3-hydroxy-3-methylglutaryl-...