Elevated AA/EPA Ratio Represents an Inflammatory Biomarker in Tumor Tissue of Metastatic Colorectal Cancer Patients

• Published in: International journal of molecular sciences Vol. 20; no. 8; p. 2050
• Main Authors: Tutino, Valeria, De Nunzio, Valentina, Caruso, Maria Gabriella, Veronese, Nicola, Lorusso, Dionigi, Di Masi, Marta, Benedetto, Maria Lucrezia, Notarnicola, Maria
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 25.04.2019; MDPI
• Subjects: Biomarkers; Colorectal cancer; Enzymes; Fatty acids; Gene expression; Inflammation; Ligands; Membranes; Metabolism; Metastasis; Proteins; Studies; Tumor necrosis factor-TNF; Tumorigenesis; eicosapentaenoic acid; colorectal cancer; Arachidonic acid; metastasis; inflammatory biomarker

Chronic inflammation increases the risk of developing certain types of cancer, such as colorectal cancer (CRC). The oxidative metabolism of polyunsaturated fatty acids (PUFAs) has a strong effect on colonic tumorigenesis and the levels of arachidonic acid (AA) and eicosapentaenoic acid (EPA) can con...