Erinacine A-Enriched Hericium erinaceus Mycelium Produces Antidepressant-Like Effects through Modulating BDNF/PI3K/Akt/GSK-3β Signaling in Mice

• Published in: International journal of molecular sciences Vol. 19; no. 2; p. 341
• Main Authors: Chiu, Chun-Hung, Chyau, Charng-Cherng, Chen, Chin-Chu, Lee, Li-Ya, Chen, Wan-Ping, Liu, Jia-Ling, Lin, Wen-Hsin, Mong, Mei-Chin
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 24.01.2018; MDPI
• Subjects: Tumor necrosis factor-TNF; erinacine A; inflammation; restraint stress; Hericium erinaceus; antidepressant; monoamines

Antidepressant-like effects of ethanolic extract of Hericium erinaceus (HE) mycelium enriched in erinacine A on depressive mice challenged by repeated restraint stress (RS) were examined. HE at 100, 200 or 400 mg/kg body weight/day was orally given to mice for four weeks. After two weeks of HE admin...