Genetic landscape for majority and minority HIV-1 drug resistance mutations in antiretroviral therapy naive patients in Accra, Ghana

• Published in: Heliyon Vol. 10; no. 12; p. e33180
• Main Authors: Appiah, Pious, Gbassana, Gaspah, Adusei-Poku, Mildred, Obeng, Billal Musah, Duedu, Kwabena Obeng, Sagoe, Kwamena William Coleman
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 30.06.2024; Elsevier
• Subjects: HIV drug resistance; Minority drug-resistance mutations; Next-generation sequencing; Quasispecies; Virological failure; Minority drug-resistance mutations; Quasispecies; Virological failure; Next-generation sequencing; HIV drug resistance

The successful detection of drug-resistance mutations (DRMs) in HIV-1 infected patients has improved the management of HIV infection. Next-generation sequencing (NGS) to detect low-frequency mutations is predicted to be useful for efficiently testing minority drug resistance mutations, which could c...