TMPRSS2 Contributes to Virus Spread and Immunopathology in the Airways of Murine Models after Coronavirus Infection

• Published in: Journal of virology Vol. 93; no. 6
• Main Authors: Iwata-Yoshikawa, Naoko, Okamura, Tadashi, Shimizu, Yukiko, Hasegawa, Hideki, Takeda, Makoto, Nagata, Noriyo
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 15.03.2019
• Subjects: Animals; Cell Line; Chlorocebus aethiops; Coronavirus Infections - immunology; Coronavirus Infections - metabolism; Coronavirus Infections - virology; Disease Models, Animal; Female; Humans; Lung - immunology; Lung - metabolism; Lung - virology; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Middle East Respiratory Syndrome Coronavirus - immunology; Pathogenesis and Immunity; Poly I-C - metabolism; SARS Virus; Serine Endopeptidases - metabolism; Severe Acute Respiratory Syndrome - immunology; Severe Acute Respiratory Syndrome - metabolism; Severe Acute Respiratory Syndrome - virology; Spike Glycoprotein, Coronavirus - metabolism; Toll-Like Receptor 3 - metabolism; Vero Cells; TMPRSS2; MERS-CoV; immunopathology; animal model; SARS-CoV

Broad-spectrum antiviral drugs against highly pathogenic coronaviruses and other emerging viruses are desirable to enable a rapid response to pandemic threats. Transmembrane protease serine type 2 (TMPRSS2), a protease belonging to the type II transmembrane serine protease family, cleaves the corona...