Development of a homogeneous high-throughput screening assay for biological inhibitors of human rhinovirus infection

• Published in: Journal of biomolecular screening Vol. 18; no. 3; pp. 237 - 246
• Main Authors: Newton, Philip, O'Shea, Desmond, Wells, Edward, Moakes, Kerry, Dunmore, Rebecca, Butler, Robin J, Wilkinson, Trevor, Ward, Alison, Casson, Nigel, Strain, Martin, Vousden, Katherine, Lowe, David C, Pattison, Debbie V, Carruthers, Alan M, Sleeman, Matthew A, Vaughan, Tristan J, Harrison, Paula
• Format: Journal Article
• Language: English
• Published: United States 01.03.2013
• Subjects: Antibodies - immunology; Antibodies - metabolism; Cell Line, Tumor; Fluorescence; HeLa Cells; High-Throughput Screening Assays - methods; Humans; Intercellular Adhesion Molecule-1 - immunology; Intercellular Adhesion Molecule-1 - metabolism; Picornaviridae Infections - immunology; Picornaviridae Infections - metabolism; Rhinovirus - immunology; Rhinovirus - metabolism

Infection with human rhinovirus (HRV) is thought to result in acute respiratory exacerbations of chronic obstructive pulmonary disorder (COPD). Consequently, prevention of HRV infection may provide therapeutic benefit to these patients. As all major group HRV serotypes infect cells via an interactio...