Development of mucoadhesive sprayable gellan gum fluid gels

• Published in: International journal of pharmaceutics Vol. 488; no. 1-2; pp. 12 - 19
• Main Authors: Mahdi, Mohammed H., Conway, Barbara R., Smith, Alan M.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 05.07.2015
• Subjects: Administration, Intranasal; Aerosols - chemistry; Caffeine; Chemistry, Pharmaceutical; Drug Delivery Systems; Fluid gel; Gellan gum; Gels - chemistry; Modified release; Mucoadhesion; Nasal Mucosa; Nasal spray; Polymers; Polysaccharides, Bacterial - chemistry; Rheology; Technology, Pharmaceutical - methods; Viscosity; Gellan gum; Fluid gel; Modified release; Mucoadhesion; Nasal spray; Caffeine

[Display omitted] The nasal mucosa provides a potentially good route for local and systemic drug delivery. However, the protective feature of the nasal cavity make intranasal delivery challenging. The application of mucoadhesive polymers in nasal drug delivery systems enhances the retention of the d...