Mechanisms and Implications of Dual-Acting Methotrexate in Folate-Targeted Nanotherapeutic Delivery

• Published in: International journal of molecular sciences Vol. 16; no. 1; pp. 1772 - 1790
• Main Authors: Wong, Pamela, Choi, Seok
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 13.01.2015; MDPI
• Subjects: Animals; Antimetabolites, Antineoplastic - administration & dosage; Antimetabolites, Antineoplastic - chemistry; Biomarkers; Cancer; Dendrimers - chemistry; Dendrimers - metabolism; Drug Carriers - chemistry; Drug Carriers - metabolism; Drug Delivery Systems; Folate Receptors, GPI-Anchored - chemistry; Folate Receptors, GPI-Anchored - metabolism; Folic Acid - chemistry; Folic Acid - metabolism; Humans; Methotrexate - administration & dosage; Methotrexate - chemistry; Models, Molecular; Nanoparticles; Nanoparticles - chemistry; Nanoparticles - metabolism; Neoplasms - drug therapy; Neoplasms - metabolism; Review; Vitamin B

The rational design of a nanoplatform in drug delivery plays a crucial role in determining its targeting specificity and efficacy in vivo. A conventional approach relies on the surface conjugation of a nanometer-sized particle with two functionally distinct types of molecules, one as a targeting lig...