Causes and Consequences of Purifying Selection on SARS-CoV-2

• Published in: Genome biology and evolution Vol. 13; no. 10
• Main Authors: Morales, Atahualpa Castillo, Rice, Alan M, Ho, Alexander T, Mordstein, Christine, Mühlhausen, Stefanie, Watson, Samir, Cano, Laura, Young, Bethan, Kudla, Grzegorz, Hurst, Laurence D
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.10.2021
• Subjects: Codon Usage; Codon, Nonsense; COVID-19 - virology; Evolution, Molecular; Humans; Models, Genetic; Mutation; Mutation Rate; Mutation, Missense; Polymorphism, Single Nucleotide; SARS-CoV-2 - genetics; Selection, Genetic; Silent Mutation; SARS-CoV-2; purifying selection; mutation rate; codon usage

Abstract Owing to a lag between a deleterious mutation’s appearance and its selective removal, gold-standard methods for mutation rate estimation assume no meaningful loss of mutations between parents and offspring. Indeed, from analysis of closely related lineages, in SARS-CoV-2, the Ka/Ks ratio wa...