A First-in-Human Phase 1 Study of a Tumor-Directed RNA-Interference Drug against HIF2α in Patients with Advanced Clear Cell Renal Cell Carcinoma - Brugarolas, James; Obara, Gregory; Beckermann, Kathryn E.; Rini, Brian; Lam, Elaine T.; Hamilton, James; Schluep, Thomas; Yi, Min; Wong, So; Mao, Zhongping Lily; Gamelin, Erick; Tannir, Nizar M. (Clinical cancer research, 2024)
Keywords: Adult; Aged; Aged, 80 and over; Antineoplastic Agents - administration & dosage; Antineoplastic Agents - adverse effects; Basic Helix-Loop-Helix Transcription Factors - genetics; Biological Agents & Therapies; Carcinoma, Renal Cell - drug therapy; Carcinoma, Renal Cell - genetics; Carcinoma, Renal Cell - pathology; Clinical Trial Results; Clinical Trials: Targeted Therapy; Female; Genitourinary Cancers; Humans; Kidney Neoplasms - drug therapy; Kidney Neoplasms - genetics; Kidney Neoplasms - pathology; Male; Middle Aged; RNA Interference; RNA, Small Interfering - administration & dosage; RNA, Small Interfering - genetics