Synthetic peptides derived from the Schistosoma mansoni secretory protein Sm16 induce contrasting responses in hepatic stellate cells

• Published in: Experimental parasitology Vol. 236-237; p. 108255
• Main Authors: Carson, Jack P., Robinson, Mark W., Ramm, Grant A., Gobert, Geoffrey N.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.05.2022
• Subjects: Fibrosis; Hepatic stellate cell; LX-2; Schistosoma mansoni; Sm16; Sm16; Schistosoma mansoni; LX-2; Hepatic stellate cell; Fibrosis

Sm16 is a 16 KDa protein released by Schistosoma mansoni that modulates inflammatory responses in host cells. Sm16 is expressed by several life cycle stages of S. mansoni, including the egg stage. Schistosome eggs are known to provoke chronic schistosomiasis pathology, which involves the development...