Commensal gut bacteria modulate phosphorylation-dependent PPARγ transcriptional activity in human intestinal epithelial cells

• Published in: Scientific reports Vol. 7; no. 1; p. 43199
• Main Authors: Nepelska, Malgorzata, de Wouters, Tomas, Jacouton, Elsa, Béguet-Crespel, Fabienne, Lapaque, Nicolas, Doré, Joël, Arulampalam, Velmurugesan, Blottière, Hervé M.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 07.03.2017; Nature Publishing Group
• Subjects: 38; 38/47; 631/326/88; 631/80/86/388; Angiopoietin-like 4 Protein - metabolism; Bacteria, Anaerobic - growth & development; Bacteria, Anaerobic - metabolism; Butyrates - metabolism; Cell Culture Techniques; Cell Line; Culture Media, Conditioned; Epithelial Cells - physiology; Gastrointestinal Microbiome; Gene Expression Regulation; Humanities and Social Sciences; Humans; Intestinal Mucosa - physiology; Life Sciences; MAP Kinase Signaling System; multidisciplinary; Perilipin-2 - metabolism; Phosphorylation; PPAR gamma - metabolism; Propionates - metabolism; Protein Processing, Post-Translational; Science

In healthy subjects, the intestinal microbiota interacts with the host’s epithelium, regulating gene expression to the benefit of both, host and microbiota. The underlying mechanisms remain poorly understood, however. Although many gut bacteria are not yet cultured, constantly growing culture collec...