The inhibitory effects of NKX3.1 on IGF-1R expression and its signalling pathway in human prostatic carcinoma PC3 cells

• Published in: Asian journal of andrology Vol. 14; no. 3; pp. 493 - 498
• Main Authors: Zhang, Peng-Ju, Hu, Xiao-Yan, Liu, Chun-Yan, Chen, Zhao-Bo, Ni, Na-Na, Yu, Yang, Yang, Li-Na, Huang, Zhao-Qin, Liu, Qing-Wei, Jiang, An-Li
• Format: Journal Article
• Language: English
• Published: China Medknow Publications & Media Pvt. Ltd 01.05.2012; Nature Publishing Group
• Subjects: Adenocarcinoma - drug therapy; Adenocarcinoma - genetics; Adenocarcinoma - metabolism; Cell Line, Tumor; Cell Proliferation - drug effects; Down-Regulation; Gene Expression Regulation, Neoplastic - drug effects; Gene Expression Regulation, Neoplastic - genetics; Homeodomain Proteins - genetics; Homeodomain Proteins - metabolism; Humans; Insulin-Like Growth Factor I - pharmacology; Male; Original; Prostatic Neoplasms - drug therapy; Prostatic Neoplasms - genetics; Prostatic Neoplasms - metabolism; Receptor, IGF Type 1 - genetics; Receptor, IGF Type 1 - metabolism; RNA, Messenger - metabolism; Signal Transduction - drug effects; Transcription Factors - genetics; Transcription Factors - metabolism; Transfection

NKX3.1, which is a prostate-specific homeobox gene, plays an important role in prostate cancer and usually functions as a tumour suppressor gene. In this study, we investigated the inhibitory effect of NKX3.1 on insulin-like growth factor (IGF)-1R expression and its downstream signalling pathway in...