Evidence for serum miR-15a and miR-16 levels as biomarkers that distinguish sepsis from systemic inflammatory response syndrome in human subjects

• Published in: Clinical chemistry and laboratory medicine Vol. 50; no. 8; pp. 1423 - 1428
• Main Authors: Wang, Huijuan, Zhang, Pengjun, Chen, Weijun, Feng, Dan, Jia, Yanhong, Xie, Li-xin
• Format: Journal Article
• Language: English
• Published: Berlin Walter de Gruyter 01.08.2012; De Gruyter
• Subjects: Adult; Aged; Aged, 80 and over; Bacterial diseases; Bacterial sepsis; Biological and medical sciences; Biomarkers - blood; Cross-Sectional Studies; diagnosis; Diagnosis, Differential; Female; General aspects; Human bacterial diseases; Humans; Infectious diseases; Investigative techniques, diagnostic techniques (general aspects); Male; Medical sciences; MicroRNAs - blood; Middle Aged; miR-15a; miR-16; Reverse Transcriptase Polymerase Chain Reaction; sepsis; Sepsis - blood; Sepsis - diagnosis; Sepsis - genetics; Systemic Inflammatory Response Syndrome - blood; Systemic Inflammatory Response Syndrome - diagnosis; Young Adult; Human; Biological marker; Biological indicator; Inflammation; miR-15a; Bacteremia; Infection; Medicine; Sepsis syndrome; miR-16; Systemic inflammatory response syndrome; Clinical biology; Bacteriosis; Serum; Diagnosis; sepsis

: Serum microRNAs may be useful biomarkers for diagnosing human diseases. We investigated serum levels of miR-15a and miR-16 in patients with sepsis and systemic inflammatory response syndrome (SIRS) without infection. : We enrolled 166 sepsis patients, 32 SIRS patients, and 24 normal controls. Seru...