The Role of Peroxisome Proliferator-Activated Receptors and Their Transcriptional Coactivators Gene Variations in Human Trainability: A Systematic Review

• Published in: International journal of molecular sciences Vol. 19; no. 5; p. 1472
• Main Authors: Petr, Miroslav, Stastny, Petr, Zajac, Adam, Tufano, James, Maciejewska-Skrendo, Agnieszka
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 15.05.2018; MDPI
• Subjects: Adult; Aerobics; Aged; Carrier Proteins - genetics; Humans; Male; Middle Aged; Muscle, Skeletal - metabolism; Muscle, Skeletal - physiology; Oxygen Consumption; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - genetics; Peroxisome Proliferator-Activated Receptors - genetics; Physical Conditioning, Human; Physical fitness; Polymorphism, Single Nucleotide; Product lines; Review; RNA-Binding Proteins; mitochondria activity; VO2peak; aerobic training; insulin response; anaerobic threshold; genetic predisposition; muscle fibers; VO2max; cholesterol levels; human performance; glucose tolerance

Background: The peroxisome proliferator-activated receptors (PPARA, PPARG, PPARD) and their transcriptional coactivators’ (PPARGC1A, PPARGC1B) gene polymorphisms have been associated with muscle morphology, oxygen uptake, power output and endurance performance. The purpose of this review is to deter...