Participation of c-FLIP in NLRP3 and AIM2 inflammasome activation

• Published in: Cell death and differentiation Vol. 21; no. 3; pp. 451 - 461
• Main Authors: Wu, Y-H, Kuo, W-C, Wu, Y-J, Yang, K-T, Chen, S-T, Jiang, S-T, Gordy, C, He, Y-W, Lai, M-Z
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 01.03.2014
• Subjects: Animals; Apoptosis; Bone marrow; Carrier Proteins - genetics; Carrier Proteins - metabolism; CASP8 and FADD-Like Apoptosis Regulating Protein - metabolism; Cell death; DNA-Binding Proteins - genetics; DNA-Binding Proteins - metabolism; Down-Regulation; HEK293 Cells; Humans; Immunology; Inflammasomes - metabolism; Interleukin-1beta - metabolism; Laboratory animals; Ligands; Listeria; Macrophages - metabolism; Mice; Molecular biology; NLR Family, Pyrin Domain-Containing 3 Protein; Original Paper; Peptides; Proteins; Signal Transduction; Uric acid; Taiwan

Cellular FLICE-inhibitory protein (c-FLIP) is an inhibitor of caspase-8 and is required for macrophage survival. Recent studies have revealed a selective role of caspase-8 in noncanonical IL-1β production that is independent of caspase-1 or inflammasome. Here we demonstrated that c-FLIP(L) is an une...