Sperm DNA Fragmentation and Sperm-Borne miRNAs: Molecular Biomarkers of Embryo Development?

• Published in: International journal of molecular sciences Vol. 24; no. 2; p. 1007
• Main Authors: Conflitti, Anna Chiara, Cicolani, Gaia, Buonacquisto, Alessandra, Pallotti, Francesco, Faja, Fabiana, Bianchini, Serena, Blaconà, Giovanna, Bruno, Sabina Maria, Linari, Antonella, Lucarelli, Marco, Montanino, Diletta, Muzii, Ludovico, Lenzi, Andrea, Lombardo, Francesco, Paoli, Donatella
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 05.01.2023; MDPI
• Subjects: Biomarkers; Cell division; DNA Fragmentation; Embryonic Development - genetics; Embryos; Epigenetics; Fertilization in Vitro; Humans; Infertility; Male; MicroRNAs - genetics; Morphology; Motility; Regression analysis; Semen; Semen Analysis; Sperm; Sperm Injections, Intracytoplasmic; Spermatogenesis; Spermatozoa; miR-449b-5p; embryo development; Intracytoplasmic Sperm Injection; sperm-borne miRNA; miR-34c-5p; Sperm DNA Fragmentation

The evaluation of morpho-functional sperm characteristics alone is not enough to explain infertility or to predict the outcome of Assisted Reproductive Technologies (ART): more sensitive diagnostic tools are needed in clinical practice. The aim of the present study was to analyze Sperm DNA Fragmenta...