Correlative Study on Impaired Prostaglandin E2 Regulation in Epicardial Adipose Tissue and Its Role in Maladaptive Cardiac Remodeling via EPAC2 and ST2 Signaling in Overweight Cardiovascular Disease Subjects

• Published in: International journal of molecular sciences Vol. 21; no. 2; p. 520
• Main Authors: Vianello, Elena, Dozio, Elena, Bandera, Francesco, Froldi, Marco, Micaglio, Emanuele, Lamont, John, Tacchini, Lorenza, Schmitz, Gerd, Corsi Romanelli, Massimiliano Marco
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 14.01.2020; MDPI
• Subjects: Adipocytes; Biosynthesis; Body fat; Cardiovascular disease; Ejection fraction; Enzymes; Heart; Inflammation; Insulin resistance; Metabolism; Obesity; Overweight; Proteins; EP4 receptor; EP3 receptor; Cardiovascular Diseases (CVDs); fat mass; exchange protein directly activated by cAMP isoform 2 (EPAC2); interleukin(IL)-33; prostaglandin E2 (PGE2); stimulating growth factor 2 (ST2); epicardial adipose tissue (EAT)

There is recent evidence that the dysfunctional responses of a peculiar visceral fat deposit known as epicardial adipose tissue (EAT) can directly promote cardiac enlargement in the case of obesity. Here, we observed a newer molecular pattern associated with LV dysfunction mediated by prostaglandin...