Transcriptional Modulation of the Hippo Signaling Pathway by Drugs Used to Treat Bipolar Disorder and Schizophrenia

• Published in: International journal of molecular sciences Vol. 22; no. 13; p. 7164
• Main Authors: Panizzutti, Bruna, Bortolasci, Chiara C., Spolding, Briana, Kidnapillai, Srisaiyini, Connor, Timothy, Richardson, Mark F., Truong, Trang T. T., Liu, Zoe S. J., Morris, Gerwyn, Gray, Laura, Hyun Kim, Jee, Dean, Olivia M., Berk, Michael, Walder, Ken
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 02.07.2021; MDPI
• Subjects: Alzheimer's disease; Apoptosis; Bipolar disorder; Bipolar Disorder - drug therapy; Cell Line, Tumor; Drugs; Gene Expression Regulation - drug effects; Hippo Signaling Pathway; Humans; Insects; Nervous system; Pathophysiology; Protein Serine-Threonine Kinases - genetics; Protein Serine-Threonine Kinases - metabolism; Psychotropic drugs; Psychotropic Drugs - pharmacology; Psychotropic Drugs - therapeutic use; Schizophrenia; Schizophrenia - drug therapy; Signal Transduction - drug effects; Transcription factors; Transcription Factors - metabolism; bipolar disorder; Hippo pathway; drug repurposing; inflammation; neuroscience; connectivity map; psychiatry; schizophrenia; psychotropic drugs

Recent reports suggest a link between positive regulation of the Hippo pathway with bipolar disorder (BD), and the Hippo pathway is known to interact with multiple other signaling pathways previously associated with BD and other psychiatric disorders. In this study, neuronal-like NT2 cells were trea...