Metformin Enhances Nomegestrol Acetate Suppressing Growth of Endometrial Cancer Cells and May Correlate to Downregulating mTOR Activity In Vitro and In Vivo

• Published in: International journal of molecular sciences Vol. 20; no. 13; p. 3308
• Main Authors: Cao, Can, Zhou, Jie-yun, Xie, Shu-wu, Guo, Xiang-jie, Li, Guo-ting, Gong, Yi-juan, Yang, Wen-jie, Li, Zhao, Zhong, Rui-hua, Shao, Hai-hao, Zhu, Yan
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 05.07.2019; MDPI
• Subjects: Adaptor Proteins, Signal Transducing; Animals; Antidiabetics; Apoptosis; Apoptosis - drug effects; Cancer therapies; Cell cycle; Cell Cycle Checkpoints - drug effects; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation - drug effects; Chemotherapy; Deoxyribonucleic acid; DNA; Down-Regulation - drug effects; Endocrine therapy; Endometrial cancer; Endometrial Neoplasms - enzymology; Endometrial Neoplasms - pathology; Estrogen Receptor alpha - metabolism; Eukaryotic Initiation Factor-4G - metabolism; Female; Gynecology; Humans; Investigations; Kinases; Medical prognosis; Megestrol - chemistry; Megestrol - pharmacology; Menstruation; Metformin - chemistry; Metformin - pharmacology; Mice, Nude; Norpregnadienes - chemistry; Norpregnadienes - pharmacology; Phosphorylation - drug effects; Proteins; Receptors, Progesterone - metabolism; TOR Serine-Threonine Kinases - metabolism; Tumor Suppressor Protein p53 - metabolism; Tumors; Xenograft Model Antitumor Assays; endometrial cancer; nomegestrol acetate; progestins; apoptosis; metformin; mTOR signaling

This study investigated the effect of a novel progestin and its combination with metformin on the growth of endometrial cancer (EC) cells. Inhibitory effects of four progestins, including nomegestrol acetate (NOMAC), medroxyprogesterone acetate, levonorgestrel, and cyproterone acetate, were evaluate...