Metformin Enhances Nomegestrol Acetate Suppressing Growth of Endometrial Cancer Cells and May Correlate to Downregulating mTOR Activity In Vitro and In Vivo - Cao, Can; Zhou, Jie-yun; Xie, Shu-wu; Guo, Xiang-jie; Li, Guo-ting; Gong, Yi-juan; Yang, Wen-jie; Li, Zhao; Zhong, Rui-hua; Shao, Hai-hao; Zhu, Yan (International journal of molecular sciences, 2019)
Keywords: Adaptor Proteins, Signal Transducing; Animals; Antidiabetics; Apoptosis; Apoptosis - drug effects; Cancer therapies; Cell cycle; Cell Cycle Checkpoints - drug effects; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation - drug effects; Chemotherapy; Deoxyribonucleic acid; DNA; Down-Regulation - drug effects; Endocrine therapy; Endometrial cancer; Endometrial Neoplasms - enzymology; Endometrial Neoplasms - pathology; Estrogen Receptor alpha - metabolism; Eukaryotic Initiation Factor-4G - metabolism; Female; Gynecology; Humans; Investigations; Kinases; Medical prognosis; Megestrol - chemistry; Megestrol - pharmacology; Menstruation; Metformin - chemistry; Metformin - pharmacology; Mice, Nude; Norpregnadienes - chemistry; Norpregnadienes - pharmacology; Phosphorylation - drug effects; Proteins; Receptors, Progesterone - metabolism; TOR Serine-Threonine Kinases - metabolism; Tumor Suppressor Protein p53 - metabolism; Tumors; Xenograft Model Antitumor Assays; endometrial cancer; nomegestrol acetate; progestins; apoptosis; metformin; mTOR signaling