Association of variants in HTRA1 and NOTCH3 with MRI-defined extremes of cerebral small vessel disease in older subjects - Mishra, Aniket; Chauhan, Ganesh; Violleau, Marie-Helene; Vojinovic, Dina; Jian, Xueqiu; Bis, Joshua C; Li, Shuo; Saba, Yasaman; Grenier-Boley, Benjamin; Yang, Qiong; Bartz, Traci M; Hofer, Edith; et al. (Brain (London, England : 1878), 2019)
Keywords: Aged; Aged, 80 and over; Brain Ischemia - genetics; Cerebral Small Vessel Diseases - diagnostic imaging; Cerebral Small Vessel Diseases - genetics; Cerebral Small Vessel Diseases - metabolism; Cohort Studies; Exome Sequencing - methods; Female; Genetics; Geriatry and gerontology; Heterozygote; High-Temperature Requirement A Serine Peptidase 1 - genetics; High-Temperature Requirement A Serine Peptidase 1 - metabolism; Human genetics; Human health and pathology; Humans; Life Sciences; Magnetic Resonance Imaging; Male; Middle Aged; Mutation; Neurobiology; Neurons and Cognition; Original; Polymorphism, Single Nucleotide; Populations and Evolution; Receptor, Notch3 - genetics; Receptor, Notch3 - metabolism; Receptor, Notch3 - physiology; Stroke - genetics; White Matter - diagnostic imaging; White Matter - metabolism; exome sequencing study; cerebral small vessel disease; lacunes of presumed vascular origin; extreme phenotype; white matter hyperintensity