FcεRI-HDAC3-MCP1 Signaling Axis Promotes Passive Anaphylaxis Mediated by Cellular Interactions

• Published in: International journal of molecular sciences Vol. 20; no. 19; p. 4964
• Main Authors: Kim, Misun, Kwon, Yoojung, Jung, Hyun Suk, Kim, Youngmi, Jeoung, Dooil
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 08.10.2019; MDPI
• Subjects: Allergens; Anaphylaxis; Anaphylaxis - drug therapy; Anaphylaxis - etiology; Anaphylaxis - metabolism; Animals; Antibodies; Cancer; Cell Communication; Chemokine CCL2 - metabolism; Cytokines; Dermatitis; Disease Susceptibility; Food allergies; Gene expression; Histamine; Histone Deacetylase Inhibitors - pharmacology; Histone Deacetylase Inhibitors - therapeutic use; Histone Deacetylases - metabolism; Human subjects; Humans; Immunoglobulin E - immunology; Immunoglobulin G - immunology; Inflammation; MicroRNAs; MicroRNAs - genetics; Neutrophils; Receptors, IgE - metabolism; Review; Signal Transduction; Anaphylaxis, cellular interactions, FcεRI, HDAC3, MCP1, miRNAs

Anaphylaxis is an acute and life-threatening systemic reaction. Food, drug, aero-allergen and insect sting are known to induce anaphylaxis. Mast cells and basophils are known to mediate Immunoglobulin E (IgE)-dependent anaphylaxis, while macrophages, neutrophils and basophils mediate non IgE-depende...