BMP-9 induces proliferation of multiple types of endothelial cells in vitro and in vivo

• Published in: Journal of cell science Vol. 123; no. 10; pp. 1684 - 1692
• Main Authors: Suzuki, Yuka, Ohga, Noritaka, Morishita, Yasuyuki, Hida, Kyoko, Miyazono, Kohei, Watabe, Tetsuro
• Format: Journal Article
• Language: English
• Published: England The Company of Biologists Limited 15.05.2010
• Subjects: Activin Receptors, Type II - metabolism; Adenocarcinoma - drug therapy; Adenocarcinoma - genetics; Adenocarcinoma - metabolism; Adenocarcinoma - pathology; Allantois - metabolism; Animals; Blood Vessels - drug effects; Blood Vessels - embryology; Cell Line, Tumor; Cell Proliferation - drug effects; Embryo, Mammalian; Endothelial Cells - drug effects; Endothelial Cells - metabolism; Endothelial Cells - pathology; Gene Expression Regulation, Developmental; Growth Differentiation Factor 2 - pharmacology; Humans; Mice; Mice, Inbred BALB C; Mice, Inbred ICR; Neoplasm Transplantation; Neovascularization, Physiologic - drug effects; Pancreatic Neoplasms - drug therapy; Pancreatic Neoplasms - genetics; Pancreatic Neoplasms - metabolism; Pancreatic Neoplasms - pathology; Signal Transduction - drug effects

Members of the bone morphogenetic protein (BMP) family have been implicated in the development and maintenance of vascular systems. Whereas members of the BMP-2/4 and osteogenic protein-1 groups signal via activin receptor-like kinase (ALK)-2, ALK-3 and ALK-6, BMP-9 and BMP-10 have been reported to...