Photoprotective Role of Photolyase-Interacting RAD23 and Its Pleiotropic Effect on the Insect-Pathogenic Fungus Beauveria bassiana

• Published in: Applied and environmental microbiology Vol. 86; no. 11
• Main Authors: Wang, Ding-Yi, Mou, Ya-Ni, Tong, Sen-Miao, Ying, Sheng-Hua, Feng, Ming-Guang
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 19.05.2020
• Subjects: Activation; Beauveria bassiana; Biodegradation; Conidia; Cytoplasm; Cytotoxicity; Damage; Deletion mutant; Deoxyribonucleic acid; DNA; DNA repair; Fluorescence; Fungi; Gene deletion; Gene expression; Insecticide resistance; Insecticides; Insects; Invertebrate Microbiology; Lesions; Mutants; Nucleotide excision repair; Nucleotides; Phenotypes; Photolyase; Photoreactivation; Proteasomes; Repair; Transcription; Ubiquitin; Ultraviolet radiation; Vacuoles; Virulence; Yeast; DNA damage repair; entomopathogenic fungi; biological control; photolyase; UV damage; nucleotide excision repair protein; photoreactivation

RAD23 is able to repair yeast DNA lesions through nucleotide excision in full darkness, a mechanism distinct from photolyase-dependent photorepair of UV-induced DNA damage but functionally unknown in filamentous fungi. Our study unveils that the RAD23 ortholog in a filamentous fungal insect pathogen...