Blood–Brain Barrier Transporters: Opportunities for Therapeutic Development in Ischemic Stroke

• Published in: International journal of molecular sciences Vol. 23; no. 3; p. 1898
• Main Authors: Nilles, Kelsy L., Williams, Erica I., Betterton, Robert D., Davis, Thomas P., Ronaldson, Patrick T.
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 08.02.2022; MDPI
• Subjects: Animals; Blood-Brain Barrier - metabolism; Comorbidity; Disease Models, Animal; Drug therapy; Edema; Endothelium; Extracellular matrix; Gene Expression Regulation - drug effects; Glucose; Human subjects; Humans; Ischemic Stroke - drug therapy; Ischemic Stroke - metabolism; Molecular Targeted Therapy; Neuroprotective Agents - pharmacokinetics; Neuroprotective Agents - therapeutic use; Organic Anion Transporters - metabolism; Organic Cation Transport Proteins - metabolism; Permeability; Proteins; Review; Sodium; Solute movement; Stroke; blood–brain barrier; transporters; organic anion transporting polypeptides; endothelial cell; neuroprotection; statins; organic cation transporters; ischemic stroke

Globally, stroke is a leading cause of death and long-term disability. Over the past decades, several efforts have attempted to discover new drugs or repurpose existing therapeutics to promote post-stroke neurological recovery. Preclinical stroke studies have reported successes in identifying novel...