Monocyte chemotactic protein-1 is increased in the amniotic fluid of women who deliver preterm in the presence or absence of intra-amniotic infection

• Published in: The journal of maternal-fetal & neonatal medicine Vol. 17; no. 6; pp. 365 - 373
• Main Authors: Esplin, M Sean, Romero, Roberto, Chaiworapongsa, Tinnakorn, Kim, Yeon Mee, Edwin, Samuel, Gomez, Ricardo, Mazor, Moshe, Adashi, Eli Y
• Format: Journal Article
• Language: English
• Published: England Informa UK Ltd 01.06.2005; Taylor & Francis; Taylor & Francis Ltd
• Subjects: Adolescent; Adult; Amniocentesis; Amnion; amniotic fluid; Amniotic Fluid - chemistry; Amniotic Fluid - microbiology; Chemokine CCL2 - analysis; Chorioamnionitis - metabolism; Chorioamnionitis - microbiology; Delivery, Obstetric; Female; Fetal Membranes, Premature Rupture; Gestational Age; Humans; Infection; intra-amniotic infection; MCP-1; Obstetric Labor, Premature - metabolism; Pregnancy; preterm labor; preterm prelabor rupture of membranes; PROM; Time Factors

Objective. Pro-inflammatory chemokines have been associated with preterm parturition. Monocyte chemotactic protein-1 (MCP-1) is a chemokine capable of recruiting monocytes/macrophages into sites of inflammation, as well as stimulating the respiratory burst required for macrophage activation. MCP-1 t...