Novel Psychoactive Phenethylamines: Impact on Genetic Material

• Published in: International journal of molecular sciences Vol. 21; no. 24; p. 9616
• Main Authors: Cocchi, Veronica, Gasperini, Sofia, Hrelia, Patrizia, Tirri, Micaela, Marti, Matteo, Lenzi, Monia
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 17.12.2020; MDPI
• Subjects: Anisoles - pharmacology; Apoptosis; Apoptosis - drug effects; Cell Line; Cell Survival - drug effects; Conventions; Cytotoxicity; Dimethoxyphenylethylamine - analogs & derivatives; Dimethoxyphenylethylamine - pharmacology; Drugs; Ecstasy; Flow Cytometry - methods; Genes - drug effects; Hallucinogens - pharmacology; Humans; Laboratories; Methamphetamine; Micronuclei, Chromosome-Defective - chemically induced; Micronucleus Tests - methods; N-Methyl-3,4-methylenedioxyamphetamine - pharmacology; Phenethylamines - pharmacology; Psychotropic Drugs - pharmacology; Reactive oxygen species; Reactive Oxygen Species - analysis; Reactive Oxygen Species - metabolism; genotoxicity; 2C-B; phenethylamine; ROS; 2C-I; flow cytometry; 2C-H; 25B-NBOMe; MDMA

Psychedelic and stimulating phenethylamines belong to the family of new psychoactive substances (NPS). The acute toxicity framework has begun to be investigated, while studies showing genotoxic potential are very limited or not available. Therefore, in order to fill this gap, the aim of the present...