Mechanisms of Action of Autophagy Modulators Dissected by Quantitative Systems Pharmacology Analysis - Shi, Qingya; Pei, Fen; Silverman, Gary A.; Pak, Stephen C.; Perlmutter, David H.; Liu, Bing; Bahar, Ivet (International journal of molecular sciences, 2020)
Keywords: Antipsychotics; Application programming interface; Autophagy; Autophagy - drug effects; Autophagy - genetics; Biomarkers; Brain - drug effects; Brain - metabolism; Computational Biology - methods; Cyclic AMP-Dependent Protein Kinases - metabolism; Drug Discovery - methods; Drugs; Gene expression; Gene Expression Regulation - drug effects; Humans; Kinases; Liver - drug effects; Liver - metabolism; Pharmacology - methods; Phosphatidylinositol 3-Kinases - metabolism; Proteins; Signal Transduction - drug effects; Structure-Activity Relationship; TOR Serine-Threonine Kinases - metabolism; autophagy; PI3K; quantitative systems pharmacology; signal transduction; PKA; mTOR; mechanism of action; machine learning; drug-target interactions