Cardiopulmonary coupling spectrogram as an ambulatory clinical biomarker of sleep stability and quality in health, sleep apnea, and insomnia

• Published in: Sleep (New York, N.Y.) Vol. 41; no. 2
• Main Authors: Thomas, Robert Joseph, Wood, Christopher, Bianchi, Matt Travis
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 01.02.2018
• Subjects: Biomarkers; Electrocardiography; Insomnia; Sleep apnea; Sleep, Health and Disease; apnea; sleep; ECG; ambulatory; cardiopulmonary coupling; insomnia
• DOI: 10.1093/sleep/zsx196
• ISSN: 0161-8105; 1550-9109

Ambulatory tracking of sleep and sleep pathology is rapidly increasing with the introduction of wearable devices. The objective of this study was to evaluate a wearable device which used novel computational analysis of the electrocardiogram (ECG), collected over multiple nights, as a method to track the dynamics of sleep quality in health and disease. This study used the ECG as a primary signal, a wearable device, the M1, and an analysis of cardiopulmonary coupling to estimate sleep quality. The M1 measures trunk movements, the ECG, body position, and snoring vibrations. Data from three groups of patients were analyzed: healthy participants and people with sleep apnea and insomnia, obtained from multiple nights of recording. Analysis focused on summary measures and night-to-night variability, specifically the intraclass coefficient. Data were collected from 10 healthy participants, 18 people with positive pressure-treated sleep apnea, and 20 people with insomnia, 128, 65, and 121 nights, respectively. In any participant, all nights were consecutive. High-frequency coupling (HFC), the signal biomarker of stable breathing and stable sleep, showed high intraclass coefficients (ICCs) in healthy participants and people with sleep apnea (0.83, 0.89), but only 0.66 in people with insomnia. The only statistically significant difference between weekday and weekend in healthy subjects was HFC duration: 242.8 ± 53.8 vs. 275.8 ± 57.1 minutes (89 vs. 39 total nights), F(1,126) = 9.86, p = .002. The M1 and similar wearable devices provide new opportunities to measure sleep in dynamic ways not possible before. These measurements can yield new biological insights and aid clinical management.