β‑elemene inhibits the generation of peritoneum effusion in pancreatic cancer via suppression of the HIF1A‑VEGFA pathway based on network pharmacology

• Published in: Oncology reports Vol. 42; no. 6; pp. 2561 - 2571
• Main Authors: Zhu, Junqiu, Li, Bo, Ji, Yongsuo, Zhu, Linglin, Zhu, Yanfei, Zhao, Hong
• Format: Journal Article
• Language: English
• Published: Greece Spandidos Publications UK Ltd 01.12.2019; D.A. Spandidos
• Subjects: Aged; Angiogenesis; Antigens; Apoptosis; Ascites - etiology; Ascitic Fluid - cytology; Ascitic Fluid - drug effects; Cancer therapies; Cell Line, Tumor; Chemotherapy; Chinese medicine; Datasets as Topic; Drug Discovery - methods; Drug Screening Assays, Antitumor; FDA approval; Gene Expression Regulation, Neoplastic - drug effects; Gene Regulatory Networks - drug effects; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit - metabolism; Kaplan-Meier Estimate; Liver cancer; Male; Metastasis; Molecular Docking Simulation; Pancreatic cancer; Pancreatic Neoplasms - drug therapy; Pancreatic Neoplasms - genetics; Pancreatic Neoplasms - mortality; Pancreatic Neoplasms - pathology; Patients; Peritoneal Neoplasms - genetics; Peritoneal Neoplasms - mortality; Peritoneal Neoplasms - prevention & control; Peritoneal Neoplasms - secondary; Peritoneum - pathology; Pharmacology; Protein expression; Protein Interaction Mapping - methods; Protein Interaction Maps - drug effects; Protein Interaction Maps - genetics; Proteins; Sesquiterpenes - pharmacology; Sesquiterpenes - therapeutic use; Signal Transduction - drug effects; Signal Transduction - genetics; Simulation; Studies; Tumors; Vascular Endothelial Growth Factor A - metabolism; China

Pancreatic cancer remains one of the most lethal types of cancer. Late‑stage pancreatic cancer patients usually suffer peritoneum effusion, which severely compromises quality of life. Great efforts have been made concerning the treatment of peritoneum effusion, including treatment with β‑elemene. Al...