Clinical Pharmacokinetics and the Impact of Genetic Polymorphism on a CYP2C19 Substrate, BMS-823778, in Healthy Subjects - Gong, Jiachang; Hansen, Lars; Iacono, Lisa (Drug metabolism and disposition, 2018)
Keywords: Absorption; Adolescent; Adult; Cytochrome P-450 CYP2C19 - genetics; Cytochrome P-450 CYP3A - genetics; Double-Blind Method; Excretion; Exposure; Gene polymorphism; Genotype; Glucocorticoids; Healthy Volunteers; Humans; Male; Metabolic disorders; Metabolism; Middle Aged; Pharmacokinetics; Pharmacology; Phenotype; Phenotypes; Polymorphism; Polymorphism, Genetic - genetics; Pyridines - pharmacokinetics; Statistical analysis; Substrates; Triazoles - pharmacokinetics; Young Adult; LLOQ; AE; IM; ADME; AI; EM; CLT; AUC; LC-MS/MS; MAD; SAD; 11β-HSD1; PM