The Interplay between Angiopoietin-Like Proteins and Adipose Tissue: Another Piece of the Relationship between Adiposopathy and Cardiometabolic Diseases?

Angiopoietin-like proteins, namely ANGPTL3-4-8, are known as regulators of lipid metabolism. However, recent evidence points towards their involvement in the regulation of adipose tissue function. Alteration of adipose tissue functions (also called adiposopathy) is considered the main inducer of met...

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Published inInternational journal of molecular sciences Vol. 22; no. 2; p. 742
Main Authors Bini, Simone, D’Erasmo, Laura, Di Costanzo, Alessia, Minicocci, Ilenia, Pecce, Valeria, Arca, Marcello
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 13.01.2021
MDPI
Subjects
Adipocytes
Adipose Tissue - metabolism
Angiopoietin-like Proteins - metabolism
Animals
Body fat
Cytokines
Diabetes Mellitus, Type 2 - etiology
Diabetes Mellitus, Type 2 - metabolism
Diabetes Mellitus, Type 2 - pathology
Disease Susceptibility
Energy
Energy Metabolism
Fatty acids
Gastrointestinal surgery
Gene expression
Genotype & phenotype
Glucose
Heart Diseases - etiology
Heart Diseases - metabolism
Humans
Inflammation
Insulin Resistance
Kinases
Lipids
Lipodystrophy - etiology
Lipodystrophy - metabolism
Lipodystrophy - pathology
Metabolic Diseases - etiology
Metabolic Diseases - metabolism
Metabolism
Nutritional status
Protein Binding
Proteins
Review
Signal Transduction
Thermogenesis
Triglycerides
ANGPTL3
adipose tissue
ANGPTL4
brown adipose tissue
adiposopathy
ANGPTL8
Online AccessGet full text

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Abstract Angiopoietin-like proteins, namely ANGPTL3-4-8, are known as regulators of lipid metabolism. However, recent evidence points towards their involvement in the regulation of adipose tissue function. Alteration of adipose tissue functions (also called adiposopathy) is considered the main inducer of metabolic syndrome (MS) and its related complications. In this review, we intended to analyze available evidence derived from experimental and human investigations highlighting the contribution of ANGPTLs in the regulation of adipocyte metabolism, as well as their potential role in common cardiometabolic alterations associated with adiposopathy. We finally propose a model of ANGPTLs-based adipose tissue dysfunction, possibly linking abnormalities in the angiopoietins to the induction of adiposopathy and its related disorders.
AbstractList Angiopoietin-like proteins, namely ANGPTL3-4-8, are known as regulators of lipid metabolism. However, recent evidence points towards their involvement in the regulation of adipose tissue function. Alteration of adipose tissue functions (also called adiposopathy) is considered the main inducer of metabolic syndrome (MS) and its related complications. In this review, we intended to analyze available evidence derived from experimental and human investigations highlighting the contribution of ANGPTLs in the regulation of adipocyte metabolism, as well as their potential role in common cardiometabolic alterations associated with adiposopathy. We finally propose a model of ANGPTLs-based adipose tissue dysfunction, possibly linking abnormalities in the angiopoietins to the induction of adiposopathy and its related disorders.
Angiopoietin-like proteins, namely ANGPTL3-4-8, are known as regulators of lipid metabolism. However, recent evidence points towards their involvement in the regulation of adipose tissue function. Alteration of adipose tissue functions (also called adiposopathy) is considered the main inducer of metabolic syndrome (MS) and its related complications. In this review, we intended to analyze available evidence derived from experimental and human investigations highlighting the contribution of ANGPTLs in the regulation of adipocyte metabolism, as well as their potential role in common cardiometabolic alterations associated with adiposopathy. We finally propose a model of ANGPTLs-based adipose tissue dysfunction, possibly linking abnormalities in the angiopoietins to the induction of adiposopathy and its related disorders.Angiopoietin-like proteins, namely ANGPTL3-4-8, are known as regulators of lipid metabolism. However, recent evidence points towards their involvement in the regulation of adipose tissue function. Alteration of adipose tissue functions (also called adiposopathy) is considered the main inducer of metabolic syndrome (MS) and its related complications. In this review, we intended to analyze available evidence derived from experimental and human investigations highlighting the contribution of ANGPTLs in the regulation of adipocyte metabolism, as well as their potential role in common cardiometabolic alterations associated with adiposopathy. We finally propose a model of ANGPTLs-based adipose tissue dysfunction, possibly linking abnormalities in the angiopoietins to the induction of adiposopathy and its related disorders.
Author Arca, Marcello
Di Costanzo, Alessia
D’Erasmo, Laura
Minicocci, Ilenia
Pecce, Valeria
Bini, Simone
AuthorAffiliation Department of Translational and Precision Medicine, Sapienza University of Rome, Viale del Policlinico 155, 00185 Rome, Italy; alessia.dicostanzo@uniroma1.it (A.D.C.); ilenia.minicocci@uniroma1.it (I.M.); valeria.pecce@uniroma1.it (V.P.); marcello.arca@uniroma1.it (M.A.)
AuthorAffiliation_xml – name: Department of Translational and Precision Medicine, Sapienza University of Rome, Viale del Policlinico 155, 00185 Rome, Italy; alessia.dicostanzo@uniroma1.it (A.D.C.); ilenia.minicocci@uniroma1.it (I.M.); valeria.pecce@uniroma1.it (V.P.); marcello.arca@uniroma1.it (M.A.)
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/33451033$$D View this record in MEDLINE/PubMed
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Keywords ANGPTL3
adipose tissue
ANGPTL4
brown adipose tissue
adiposopathy
ANGPTL8
Language English
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Snippet Angiopoietin-like proteins, namely ANGPTL3-4-8, are known as regulators of lipid metabolism. However, recent evidence points towards their involvement in the...
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SubjectTerms Adipocytes
Adipose Tissue - metabolism
Angiopoietin-like Proteins - metabolism
Animals
Body fat
Cytokines
Diabetes Mellitus, Type 2 - etiology
Diabetes Mellitus, Type 2 - metabolism
Diabetes Mellitus, Type 2 - pathology
Disease Susceptibility
Energy
Energy Metabolism
Fatty acids
Gastrointestinal surgery
Gene expression
Genotype & phenotype
Glucose
Heart Diseases - etiology
Heart Diseases - metabolism
Humans
Inflammation
Insulin Resistance
Kinases
Lipids
Lipodystrophy - etiology
Lipodystrophy - metabolism
Lipodystrophy - pathology
Metabolic Diseases - etiology
Metabolic Diseases - metabolism
Metabolism
Nutritional status
Protein Binding
Proteins
Review
Signal Transduction
Thermogenesis
Triglycerides
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Title The Interplay between Angiopoietin-Like Proteins and Adipose Tissue: Another Piece of the Relationship between Adiposopathy and Cardiometabolic Diseases?
URI https://www.ncbi.nlm.nih.gov/pubmed/33451033
https://www.proquest.com/docview/2478668945
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https://pubmed.ncbi.nlm.nih.gov/PMC7828552
Volume 22
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