GLP-1RA versus placebo in patients with heart failure and mildly reduced or preserved ejection fraction: An updated meta-analysis of randomized controlled trials

• Published in: International journal of cardiology Vol. 438; p. 133604
• Main Authors: Duhan, Sanchit, Kurpad, Krishna Prasad, Keisham, Bijeta, Shtembari, Jurgen, Brener, Alina, Kanakadandi, Uday B., Garg, Anuj, Adoni, Naveed A., Mehta, Sanjay S.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.11.2025
• Subjects: GLP-1 receptor agonist; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor Agonists; Glucagon-Like Peptides - therapeutic use; Heart failure; Heart Failure - drug therapy; Heart Failure - physiopathology; Humans; Meta-analysis; Randomized controlled trials; Randomized Controlled Trials as Topic - methods; Stroke Volume - drug effects; Stroke Volume - physiology; Treatment Outcome; Heart failure; GLP-1 receptor agonist; Meta-analysis; Randomized controlled trials

Currently, limited guideline-directed medical therapies are available for heart failure (HF) with preserved and mildly reduced ejection fraction (EF). Both are associated with an increased risk of hospitalization and death, especially in overweight, obese, or diabetic individuals. We searched Cochra...