Molecular assessment of rejection and injury in lung transplant biopsies

• Published in: The Journal of heart and lung transplantation Vol. 38; no. 5; pp. 504 - 513
• Main Authors: Halloran, Kieran M., Parkes, Michael D., Chang, Jessica, Timofte, Irina L., Snell, Gregory I., Westall, Glen P., Hachem, Ramsey, Kreisel, Daniel, Trulock, Elbert, Roux, Antoine, Juvet, Stephen, Keshavjee, Shaf, Jaksch, Peter, Klepetko, Walter, Halloran, Philip F.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.05.2019
• Subjects: antibody-mediated rejection; gene expression; microarray; surfactant; T-cell‒mediated rejection; T-cell‒mediated rejection; microarray; surfactant; gene expression; antibody-mediated rejection

Improved understanding of lung transplant disease states is essential because failure rates are high, often due to chronic lung allograft dysfunction. However, histologic assessment of lung transplant transbronchial biopsies (TBBs) is difficult and often uninterpretable even with 10 pieces. We prosp...