Elective Nodal Irradiation and Patterns of Failure in Head and Neck Cancer After Primary Radiation Therapy

• Published in: International journal of radiation oncology, biology, physics Vol. 94; no. 4; pp. 775 - 782
• Main Authors: Kjems, Julie, BScMed, Gothelf, Anita B., MD, PhD, Håkansson, Katrin, MSc, Specht, Lena, MD, DMSc, Kristensen, Claus A., MD, PhD, Friborg, Jeppe, MD, PhD
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.03.2016
• Subjects: Adult; Aged; Aged, 80 and over; Analysis of Variance; CARCINOMAS; COMPUTERIZED TOMOGRAPHY; Cyclin-Dependent Kinase Inhibitor p16; Female; Follow-Up Studies; HEAD; Head and Neck Neoplasms - radiotherapy; Hematology, Oncology and Palliative Medicine; Humans; Hypopharyngeal Neoplasms - radiotherapy; Laryngeal Neoplasms - radiotherapy; LYMPH NODES; Lymphatic Irradiation; Male; Middle Aged; Mouth Neoplasms - radiotherapy; NECK; Neoplasm Proteins - analysis; Neoplasm Recurrence, Local - epidemiology; ORAL CAVITY; Oropharyngeal Neoplasms - radiotherapy; PATIENTS; Pharynx; Radiology; RADIOLOGY AND NUCLEAR MEDICINE; RADIOTHERAPY; Radiotherapy Planning, Computer-Assisted; Retrospective Studies; Time Factors; Treatment Failure

Purpose The delineation of elective clinical target volumes in head and neck cancer (HNC) is important; however, the extent of lymph node levels necessary to include is debated. A comprehensive analysis of recurrence patterns in a large cohort of patients with HNC was performed, with an emphasis on...