β-Naphtoflavone and Ethanol Induce Cytochrome P450 and Protect towards MPP+ Toxicity in Human Neuroblastoma SH-SY5Y Cells

• Published in: International journal of molecular sciences Vol. 19; no. 11; p. 3369
• Main Authors: Fernandez-Abascal, Jesus, Ripullone, Mariantonia, Valeri, Aurora, Leone, Cosima, Valoti, Massimo
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 28.10.2018; MDPI
• Subjects: Brain; Cytochrome; Dopamine; Drug interactions; Ethanol; Liver; Metabolism; Neuroblastoma; Neurodegeneration; Parkinson's disease; Proteins; Toxicity; mitochondrial localization; cytochrome P450 enzyme system; xenobiotic toxicity; cytochrome P450 induction; Parkinson’s disease; neurodegeneration and neuroprotection

Cytochrome P450 (CYP) isozymes vary their expression depending on the brain area, the cell type, and the presence of drugs. Some isoforms are involved in detoxification and/or toxic activation of xenobiotics in central nervous system. However, their role in brain metabolism and neurodegeneration is...