Myostatin gene inactivation increases post-mortem calpain-dependent muscle proteolysis in mice

• Published in: Meat science Vol. 185; p. 108726
• Main Authors: Nassar, Rim, Vernus, Barbara, Carnac, Gilles, Fouret, Gilles, Goustard, Bénédicte, Casas, François, Tintignac, Lionel, Cassar-Malek, Isabelle, Picard, Brigitte, Seiliez, Iban, Brioche, Thomas, Koechlin-Ramonatxo, Christelle, Bertrand-Gaday, Christelle, Hamade, Aline, Najjar, Fadia, Chabi, Béatrice, Bonnieu, Anne
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.03.2022
• Subjects: Animals; Calpain - genetics; Calpain - metabolism; Gene Silencing; Mice; Muscle, Skeletal - metabolism; Myofibrillar protein; Myostatin - genetics; Oxidative stress; Post-mortem; Proteolysis; Skeletal muscle; Oxidative stress; Myofibrillar protein; Post-mortem; Proteolysis; Skeletal muscle

Myostatin deficiency leads to extensive skeletal muscle hypertrophy, but its consequence on post-mortem muscle proteolysis is unknown. Here, we compared muscle myofibrillar protein degradation, and autophagy, ubiquitin-proteasome and Ca2+-dependent proteolysis relative to the energetic and redox sta...