Cocaine-Induced Time-Dependent Alterations in Cytochrome P450 and Liver Function

• Published in: International journal of molecular sciences Vol. 24; no. 2; p. 1632
• Main Authors: Jastrzębska, Joanna, Daniel, Władysława Anna
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 13.01.2023; MDPI
• Subjects: Abstinence; Addictions; Addictive behaviors; Animals; Behavior; Chemical and Drug Induced Liver Injury - metabolism; Cocaine; Cytochrome; Cytochrome P-450 Enzyme System - metabolism; Dopamine; Drug dosages; Drug withdrawal; Humans; Liver - metabolism; Microsomes, Liver - metabolism; Neurons; Review; Serotonin; cytochrome P450; dopaminergic system; cocaine; liver; hepatotoxicity; addiction

Cytochrome P450 is responsible for the metabolism of endogenous substrates, drugs and substances of abuse. The brain and nervous system regulate liver cytochrome P450 via neuroendocrine mechanisms, as shown in rodents. Cocaine exerts its addictive effects through the dopaminergic system, the functio...