Experimental and computational study of the effect of breath-actuated mechanism built in the NEXThaler® dry powder inhaler

• Published in: International journal of pharmaceutics Vol. 533; no. 1; pp. 225 - 235
• Main Authors: Farkas, Árpád, Lewis, David, Church, Tanya, Tweedie, Alan, Mason, Francesca, Haddrell, Allen E., Reid, Jonathan P., Horváth, Alpár, Balásházy, Imre
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 25.11.2017
• Subjects: Adrenal Cortex Hormones - administration & dosage; Adrenal Cortex Hormones - chemistry; Aerosol drug targeting; Airway deposition modelling; Anti-Asthmatic Agents - administration & dosage; Anti-Asthmatic Agents - chemistry; Asthma - drug therapy; Asthma - metabolism; Beclomethasone - administration & dosage; Beclomethasone - chemistry; Beclomethasone dipropionate; Breath-actuated mechanism; Bronchodilator Agents - administration & dosage; Bronchodilator Agents - chemistry; Dry Powder Inhalers; Formoterol fumarate; Formoterol Fumarate - administration & dosage; Formoterol Fumarate - chemistry; Humans; Hygroscopic growth; Lung - metabolism; Models, Biological; Particle Size; Particle size distribution; Respiration; DD; FF; BH; SPC; Formoterol fumarate; Airway deposition modelling; p10; BDP; CK-EDB; LABA; Breath-actuated mechanism; GF; MOC; Aerosol drug targeting; ACI; MMAD; ACN; PIF; BAM; Hygroscopic growth; NGI; PIL; Particle size distribution; UPLC; RH; ICS; Beclomethasone dipropionate; EPF; DPI; FPF; DUSA

[Display omitted] The breath-actuated mechanism (BAM) is a mechanical unit included in NEXThaler® with the role of delaying the emission of the drug until the inhalation flow rate of the patient is sufficiently high to detach the drug particles from their carriers. The main objective of this work wa...