High-throughput microfluidics for evaluating microbubble enhanced delivery of cancer therapeutics in spheroid cultures

• Published in: Journal of controlled release Vol. 326; pp. 13 - 24
• Main Authors: Bourn, Matthew D., Batchelor, Damien V.B., Ingram, Nicola, McLaughlan, James R., Coletta, P. Louise, Evans, Stephen D., Peyman, Sally A.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 10.10.2020
• Subjects: Cell Culture Techniques; Cell Line, Tumor; Drug delivery; Humans; Microbubbles; Microfluidics; Neoplasms - drug therapy; Spheroid trap; Spheroids, Cellular; Tumor Microenvironment; Tumour-on-chip; Ultrasound; Tumour-on-chip; Microbubbles; Drug delivery; Ultrasound; Spheroid trap; Microfluidics

Drug penetration into solid tumours remains a major challenge in the effective treatment of cancer. Microbubble (MB) mediated sonoporation offers a potential solution to this by enhancing the uptake of drugs into cells. Additionally, in using an ultrasound (US) trigger, drug delivery can be localise...