Role of Macrophages in Cardioprotection

• Published in: International journal of molecular sciences Vol. 20; no. 10; p. 2474
• Main Authors: Yap, Jonathan, Cabrera-Fuentes, Hector A., Irei, Jason, Hausenloy, Derek J., Boisvert, William A.
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 19.05.2019; MDPI
• Subjects: Animals; Atherosclerosis; Blood clots; Cardiovascular disease; Cardiovascular Diseases - immunology; Cardiovascular Diseases - pathology; Cardiovascular Diseases - physiopathology; Cardiovascular Diseases - therapy; Cell growth; Chemokines; Cytokines; Embolisms; Enzymes; Genotype & phenotype; Growth factors; Heart - physiopathology; Heart attacks; Humans; Immune response; Immunity, Innate; Inflammation; Ischemia; Lipids; Macrophages - immunology; Macrophages - pathology; Myocardial Infarction - immunology; Myocardial Infarction - pathology; Myocardial Infarction - physiopathology; Myocardial Infarction - therapy; Myocardium - cytology; Myocardium - immunology; Myocardium - pathology; Pathogens; Protective Factors; Review; Smooth muscle; Stroke; Ventricular Remodeling; Wound healing; cardioprotection; macrophages; remodeling; cardiac repair; innate immune response; myocardial infarction

Cardiovascular diseases are the leading cause of mortality worldwide. It is widely known that non-resolving inflammation results in atherosclerotic conditions, which are responsible for a host of downstream pathologies including thrombosis, myocardial infarction (MI), and neurovascular events. Macro...