Phagocytic Function of Monocyte-Derived Macrophages Is Not Affected by Human Immunodeficiency Virus Type 1 Infection

• Published in: The Journal of infectious diseases Vol. 168; no. 1; pp. 84 - 91
• Main Authors: Nottet, Hans S. L. M., de Graaf, Loek, de Vos, N. Machiel, Bakker, Leendert J., van Strijp, Jos A. G., Visser, Maarten R., Verhoef, Jan
• Format: Journal Article
• Language: English
• Published: Chicago, IL The University of Chicago Press 01.07.1993; University of Chicago Press
• Subjects: AIDS/HIV; Antigens, Surface - biosynthesis; Bacteria; Bacteriophages; Biological and medical sciences; Candida albicans - immunology; Cells, Cultured; Escherichia coli - immunology; Giant cells; HIV; HIV 1; HIV Infections - immunology; HIV-1 - physiology; human immunodeficiency virus; Immunodeficiencies; Immunodeficiencies. Immunoglobulinopathies; Immunopathology; Infections; Kinetics; Macrophages; Macrophages - cytology; Macrophages - immunology; Macrophages - microbiology; Major Articles; Medical sciences; Monoclonal antibodies; Monocytes - cytology; Monocytes - microbiology; Phagocytes; Phagocytosis; Polymerase Chain Reaction; Superoxides - metabolism; Viruses; Human; Immunopathology; Cell function; Pathophysiology; AIDS; Hemopathy; Cellular immunity; Bactericidal effect; Infection; Immunological investigation; Viral disease; Phagocytosis; Macrophage

The immunopathogenesis of human immunodeficiency virus (HIV) infection is characterized by the failure to control opportunistic infections. Here, the direct effect of HIV on macrophage phagocytic function was studied. HIV-1-infected monocyte-derived macrophages expressed as many Fe-r and complement...